EuTech Scientific Services is now offering Heparin and Low Molecular Weight Heparin analysis using a variety of analytical methods, combination of these methods, and customized methods. Please contact us for more information and consultation. All work is performed in strict confidentiality.
Capillary Electrophoresis (CE) |
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| Invited guest lecture on “Validation of a CE Method for Determination of OSCS Contamination in Low Molecular Weight Heparin, Enoxaparin.” at CE Pharm 2009 in Boston on October, 2009 |
CE of Enoxaparin (Low Molecular Weight Heparin) + OSCS Impurity |
Strong Ion Exchange (SAX) Chromatography Tests A & B |
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| Test A: SAX onlyTest B: SAX + Nitrous Acid Treatment* + SAX
*Nitrous acid de-polymerizes heparin but not OSCS. Zheng et al., Journal of Medicinal Chemistry 2008, 51, 5498. |
Doneanu, C.E., Weibin, C. American Laboratory 2009, 41, 26. |
Proton NMR (1H NMR |
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| Heparin: 2.04 ppmDermatan Sulfate: 2.08 ppm
OSCS: 2.16 ppm |
Guerrini, et al., Nature Biotechnology 2008, 26, 669-675. |
