|
|
|
ANALYSIS OF HEPARIN AND LOW-MOLECULAR WEIGHT HEPARIN
EuTech Scientific Services is now offering Heparin and Low Molecular
Weight Heparin analysis using a variety of analytical methods,
combination of these methods, and customized methods. Please contact us
for more information and consultation. All work is performed in strict
confidentiality.
|
Capillary Electrophoresis (CE) |
| Invited guest lecture on "Validation of a CE
Method for Determination of OSCS Contamination in Low Molecular
Weight Heparin, Enoxaparin." at CE Pharm 2009 in Boston on
October, 2009 |
CE of Enoxaparin (Low Molecular Weight Heparin)
+ OSCS Impurity |
|
Strong Ion Exchange (SAX) Chromatography
Tests A & B |
| Test A: SAX only
Test B: SAX + Nitrous Acid Treatment* + SAX
*Nitrous acid de-polymerizes heparin but not OSCS. Zheng et
al., Journal of Medicinal Chemistry 2008, 51, 5498. |
Doneanu, C.E., Weibin, C. American Laboratory
2009, 41, 26. |
|
Proton NMR (1H NMR) |
| Heparin: 2.04 ppm
Dermatan Sulfate: 2.08 ppm
OSCS: 2.16 ppm
|
Guerrini, et al., Nature Biotechnology 2008,
26, 669-675. |
|
